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Here, we identified MAL2 as a key player that determines the turnover of the antigen-loaded MHC-I complex and reduces the antigen presentation on tumor cells. MAL2 promotes the endocytosis of tumor antigens via direct interaction with the MHC-I complex and endosome-associated RAB proteins.
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Daha fazla öğreninSafety of workers when using the groundnut oil mill project or machinery has been given priority. It is vital for the groundnut to be cleaned properly before extraction of oil can be carried out. The kernels carry between 45-55% of oil within them which need to be extracted using the latest technological tools.
Daha fazla öğreninThe amino acid sequences of MILL1 and MILL2 are only 43% identical in the α1 domain, whereas they are 87% and 78% identical in the α2 and α3 domains, respectively. Another notable feature of MILL1 and MILL2 is that they have insertions of amino acids between the signal peptide and the α1 domain.
Daha fazla öğreninMHC class I-like protein MILL2 Curated. Alternative names. MHC class I-like located near the leukocyte receptor complex 2 1 publication. Gene names. Name. Mill2 1 publication. Organism names. Organism. Mus musculus (Mouse) Imported. Taxonomic identifier. 10090 NCBI. Taxonomic lineage.
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Daha fazla öğreninMill1 and Mill2 genes are predicted to encode membrane glycoproteins with domain organization essentially similar to that of MHC class I heavy chains. two members of the mouse MILL family, MILL1 and MILL2, are GPI-anchored glycoproteins associated with beta2-microglobulin (beta2m) Submit: New GeneRIF Correction Variation Alleles
Daha fazla öğreninATF1011, a nonmitogenic lectin for T cells purified from Aloe arborescens Mill, bound equally to normal and tumor cells [4]. One known, (2R)- (12Z,15Z)-2-hydroxy-4-oxoheneicosa-12,15-dien+ ++-1-yl acetate (1), and two novel compounds, persenone A (2) and B (3), have been isolated from avocado fruit ( Persea americana P. Mill), as …
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Daha fazla öğreninImmune evasion is a pivotal event in tumor progression. To eliminate human cancer cells, current immune checkpoint therapy is set to boost CD8+ T cell-mediated cytotoxicity. However, this action is eventually dependent on the efficient recognition of tumor-specific antigens via T cell receptors. One …
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Daha fazla öğreninStructure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility. - Abstract - Europe PMC Europe PMC is an archive of life sciences journal literature. Europe PMC Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility. 1 Europe PMCrequires Javascript to …
Daha fazla öğreninMill2 MHC I like leukocyte 2 [Mus musculus (house mouse)] - Gene - NCBI Project title: Mouse ENCODE transcriptome data Description: RNA profiling data sets generated by the Mouse ENCODE project. BioProject: PRJNA66167 Publication: PMID 25409824 Analysis date: n/a Endonuclease-mediated (4)
Daha fazla öğreninMill (MHC class I-like located near the leukocyte receptor complex) is a novel family of class I genes identified in mice that is most closely related to the human MICA/B family. In the present study, we isolated Mill cDNA from rats and carried out a comparative genomic analysis. Rats have two Mill genes orthologous to mouse Mill1 and …
Daha fazla öğreninMill1 and Mill2 genes are predicted to encode membrane glycoproteins with domain organization essentially similar to that of MHC class I heavy chains. two members of the mouse MILL family, MILL1 and MILL2, are GPI-anchored glycoproteins associated with beta2-microglobulin (beta2m)
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